Peroxisome disorders (non-Zellweger spectrum)

Disorders caused by defects in peroxisome biogenesis or function can be severe and wide-ranging in their effects. Many peroxisome disorders fall under the heading of Zellweger spectrum disorders - please see our Zellweger spectrum page for stocks related to these disorders. Non-Zellweger spectrum disorders can be found here. Please see links below and in the table for the unique characteristics associated with each disease.

General information links for Peroxisome disorders:

Causative genes for Peroxisome disorders
DisorderHuman geneHuman proteinFly Gene
Peroxisomal acyl-CoA oxidase deficiencyACOX1Acyl-CoA oxidase 1, palmitoylCG5009
Rhizomelic chondrodysplasia punctata, type 1PEX7Peroxisome biogenesis factor 7Pex7
Rhizomelic chondrodysplasia punctata, type 3AGPSAlkylglycerone-phosphate synthaseADPS
Refsum diseasePHYHPhytanoyl-CoA hydrolaseCG14688
AdrenoleukodystrophyABCD1ATP-binding cassette, subfamily D, member 1ABCD

Stocks for studying Peroxisome disorders
Relevant gene in stockFly disease model or related mutation or transgeneStk #Comments
Abcd1605964Frameshift deletion of 4:188939 resulting in the addition of QRPKSYWLHSSLKKKLQII after leucine 80 in all Abcd1 isoforms and premature truncation.
Abcd1Abcd1[A]602199A deletion of bp 4:188931 to 4:188940 (R6) results in a frameshift that adds KSYWLHSSLKKKLQIIstop after Leu80 in all Abcd1 isoforms.
Abcd1P{TRiP.HMS02382}attP241984Expresses dsRNA for RNAi of CG2316 (FBgn0039890) under UAS control.
Abcd1Mi{Trojan-GAL4.2}Abcd1[MI11268-TG4.2]78384Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of GAL4 under the control of CG2316 regulatory sequences and a truncated ABCD protein.
Abcd1Mi{DH.2}Abcd1[MI11268-DH.PT-GFSTF.2]94778A 'Double Header' cassette in the protein trap orientation has been swapped into a Mi{MIC} resulting in expression of Abcd1 tagged with EGFP. Strong EGFP expression in 3rd instar larval brain and moderate ventral cord plus strong eye and leg disk.
Abcd1PBac{UAS-Abcd1.HA}VK0003794867Expresses HA-tagged Drosophila Abcd1 under UAS control.
Abcd1PBac{UAS-Abcd1.HA}VK0003394868Expresses HA-tagged Drosophila Abcd1 under UAS control.
Acox1P{TRiP.HMC03620}attP4052882Expresses dsRNA for RNAi of CG5009 (FBgn0027572) under UAS control.
Acox1TI{CRIMIC.TG4.1}Acox1[CR00998-TG4.1]83244CRISPR-based insertion of a CRIMIC cassette results in expression of GAL4 under CG5009 control and truncation of the CG5009 protein.
Acox1P{TKO.GS00938}attP4076490Expresses sgRNA ubiquitously for Cas9-mediated mutagenesis of CG5009 (FBgn0027572).
Acox1P{EPgy2}Acox1[EY10858]20226This P{EPgy2} insertion just 5' of CG5009 is largely uncharacterized but is oriented correctly to express CG5009 in the presence of GAL4.
Acox1P{TOE.GS00506}attP4068109Expresses sgRNAs ubiquitously for expression of CG5009 (FBgn0027572) by a Cas9-based transcriptional activator.
AgpsPBac{WH}Agps[f02060]18510This PB{WH} insertion in coding sequence (in the 3rd or 4th exon depending on the transcript) is uncharacterized but is an unverified lethal suggesting it may disrupt function.
AgpsP{TRiP.HMS01339}attP234350Expresses dsRNA for RNAi of CG10253 (FBgn0033983) under UAS control.
AgpsTI{CRIMIC.TG4.0}Agps[CR00286-TG4.0]79234CRISPR-based insertion of a CRIMIC cassette results in expression of GAL4 under ADPS control and truncation of the ADPS protein.
AgpsP{TKO.GS00970}attP4076519Expresses sgRNA ubiquitously for Cas9-mediated mutagenesis of ADPS (FBgn0033983).
AgpsP{TOE.GS01455}attP4078246Expresses sgRNAs ubiquitously for expression of ADPS (FBgn0033983) by a Cas9-based transcriptional activator.
Phyhd1Mi{MIC}Phyhd1[MI09246]51268This Mi{MIC}} insertion in the first intron transcript is uncharacterized but is an unverified lethal suggesting it may disrupt function.
Phyhd1P{TRiP.HMS05970}attP4077173Expresses dsRNA for RNAi of CG14688 (FBgn0037819) under UAS control in the VALIUM20 vector.
Phyhd1Mi{Trojan-GAL4.0}Phyhd1[MI09246-TG4.0]76703Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of GAL4 under the control of CG14688 regulatory sequences and a truncated CG14688 protein.