The Scientific Advisory Board (SAB) advises the BDSC on policy issues including acquisitions and deaccessions, coordination with other collections, cost recovery and community interactions. The SAB reports to the North American Drosophila Board.
| Hugo Bellen (Chair) | Baylor College of Medicine |
| Michelle Arbeitman | Florida State University |
| Nancy Bonini | University of Pennsylvania |
| Michael Buszczak | UT Southwestern Medical Center |
| Lynn Cooley | Yale School of Medicine |
| Oguz Kanca | Baylor College of Medicine |
| Karla Kaun | Brown University |
| Susan Parkhurst | Fred Hutchinson Cancer Research Center |
| Norbert Perrimon | Harvard Medical School |
| Nasser Rusan | National Institutes of Health |
| Benjamin White | National Institutes of Health |