Approximately 14 causative genes have been identified for nonsyndromic X-linked intellectual developmental disability (XLID). Nonsyndromic intellectual disabilities are typified by a lack of other abnormalities (syndromic X-linked intellectual developmental disabilities are generally accompanied by other specific distinguishing features). Fly stocks in the Bloomington collection that can be used to study XLID are listed here.
| XLID subtype | Human gene(s) full name | Human gene(s) symbol | Fly gene(s) |
|---|---|---|---|
| XLID1 | IQ motif- and SEC7 domain-containing protein 2 | IQSEC2 | schizo (siz) (most similar to IQSEC1) |
| XLID9 | FTSJ Homolog 1 | FTSJ1 | CG5220 |
| XLID21 | Interleukin 1 receptor accessory protein-like 1 | IL1RAPL1 | |
| XLID30 | p21-activated kinase 3 | PAK3 | p21-activated kinase (Pak) |
| XLID63 | Acyl-CoA synthetase long chain family member 3 and 4 | ACSL3 and ACSL4 | Acyl-CoA synthetase long-chain (Acsl) (most similar to ACSL3) |
| XLID72 | Ras-associated protein RAB39B | RAB39B | Rab39 |
| XLID90 | Discs large, Drosophila, homolog of, 3 | DLG3 | dlg1 (most similar to DLG1) |
| XLID93 | Bromodomain- and WD repeat-containing protein 3 | BRWD3 | BRWD3 (most similar to BWRD1) |
| XLID-Wu type | Glutamate receptor, ionotropic, AMPA 3 | GRIA3 | GluRIA and GluRIB |
| XLID106 | O-linked N-acetylglucosamine transferase | OGT | sxc |
| XLID29 | Aristaless-related homeobox, X-linked | ARX |